Results from three recent genome-sequencing trials have provided a revolutionary insight into the deadly disease.
Lung
cancer is responsible for more deaths than any other form of the
disease. Fewer than 20% of the 1.6 million cases diagnosed across the
globe every year are still alive five years later.
The trend in
new studies focuses on personalised treatment. Genome-sequencing trials
are used to match the best possible treatment to the specific genetic
make up of a patient's tumours.
In the latest trials, researchers
analysed tumour tissue samples from 183 patients suffering from lung
adenocarcinomas, 178 suffering from lung squamous cell carcinomas and
drilled-down studies of 17 tumours from smokers and non-smokers.
Author of two of the studies, Ramaswamy Govindan from the Washington University School of Medicine in St Louis, said:
"For the first time, instead of looking through a keyhole we are getting a penthouse panoramic view,"
He
added that previous studies had already looked more closely at
personalised treatment but focused on a small number of genes. In
contrast, the recent studies gleaned data across an entire genome.
Professor
Govindan, who specialises in Medical Oncology believes that these kinds
of "cataloguing studies" will revolutionise the way lung cancer
clinical trials are designed. Instead of huge, expensive trials that
feature a diverse collection of mutations, smaller studies will
laser-down into patients' tumours according to their specific mutation.
Medical experts are expecting this tailored therapy to be more
beneficial for patients suffering from cancer.
The advances of
such studies are clear - generic treatments tend to have a far greater
number of side-effects as they are simply designed to kill any rapidly
dividing cells rather than only attacking the ones spreading the
disease. Furthermore, data from the targeted studies not only forms the
basis of new treatments, they can cast light on those ones already on
the market.
Article Source: http://EzineArticles.com/7303704
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